abstract：:The tracheal system of insects is a network of epithelial tubules that functions as a respiratory organ to supply oxygen to various target organs. Target-derived signaling inputs regulate stereotyped modes of cell specification, branching morphogenesis, and collective cell migration in the embryonic stage. In the post...

journal_title：Genetics

authors： Hayashi S,Kondo T

更新日期：2018-06-01 00:00:00

abstract：:Due to issues of practicality and confidentiality of genomic data sharing on a large scale, typically only meta- or mega-analyzed genome-wide association study (GWAS) summary data, not individual-level data, are publicly available. Reanalyses of such GWAS summary data for a wide range of applications have become more ...

journal_title：Genetics

authors： Deng Y,Pan W

更新日期：2018-06-01 00:00:00

abstract：:Dna2 is a nuclease and helicase that functions redundantly with other proteins in Okazaki fragment processing, double-strand break resection, and checkpoint kinase activation. Dna2 is an essential enzyme, required for yeast and mammalian cell viability. Here, we report that numerous mutations affecting the DNA damage ...

journal_title：Genetics

authors： Markiewicz-Potoczny M,Lisby M,Lydall D

更新日期：2018-05-01 00:00:00

abstract：:As one of the world's most important food crops, the potato (Solanum tuberosum L.) has spurred innovation in autotetraploid genetics, including in the use of SNP arrays to determine allele dosage at thousands of markers. By combining genotype and pedigree information with phenotype data for economically important trai...

journal_title：Genetics

authors： Endelman JB,Carley CAS,Bethke PC,Coombs JJ,Clough ME,da Silva WL,De Jong WS,Douches DS,Frederick CM,Haynes KG,Holm DG,Miller JC,Muñoz PR,Navarro FM,Novy RG,Palta JP,Porter GA,Rak KT,Sathuvalli VR,Thompson AL,Yench

更新日期：2018-05-01 00:00:00

abstract：:The identification of genes affecting sociality can give insights into the maintenance and development of sociality and personality. In this study, we used the combination of an advanced intercross between wild and domestic chickens with a combined QTL and eQTL genetical genomics approach to identify genes for social ...

journal_title：Genetics

authors： Johnsson M,Henriksen R,Fogelholm J,Höglund A,Jensen P,Wright D

更新日期：2018-05-01 00:00:00

abstract：:Evolutionary rescue describes a situation where adaptive evolution prevents the extinction of a population facing a stressing environment. Models of evolutionary rescue could in principle be used to predict the level of stress beyond which extinction becomes likely for species of conservation concern, or, conversely, ...

journal_title：Genetics

authors： Anciaux Y,Chevin LM,Ronce O,Martin G

更新日期：2018-05-01 00:00:00

abstract：:This FlyBook chapter summarizes the history and the current state of our understanding of the Wingless signaling pathway. Wingless, the fly homolog of the mammalian Wnt oncoproteins, plays a central role in pattern generation during development. Much of what we know about the pathway was learned from genetic and molec...

journal_title：Genetics

authors： Bejsovec A

更新日期：2018-04-01 00:00:00

abstract：:Biological evolution generates a surprising amount of site-specific variability in protein sequences. Yet, attempts at modeling this process have been only moderately successful, and current models based on protein structural metrics explain, at best, 60% of the observed variation. Surprisingly, simple measures of pro...

journal_title：Genetics

authors： Jiang Q,Teufel AI,Jackson EL,Wilke CO

更新日期：2018-04-01 00:00:00

abstract：:To develop a catalog of regulatory sites in two major model organisms, Drosophila melanogaster and Caenorhabditis elegans, the modERN (model organism Encyclopedia of Regulatory Networks) consortium has systematically assayed the binding sites of transcription factors (TFs). Combined with data produced by our predecess...

journal_title：Genetics

authors： Kudron MM,Victorsen A,Gevirtzman L,Hillier LW,Fisher WW,Vafeados D,Kirkey M,Hammonds AS,Gersch J,Ammouri H,Wall ML,Moran J,Steffen D,Szynkarek M,Seabrook-Sturgis S,Jameel N,Kadaba M,Patton J,Terrell R,Corson M,Dur

更新日期：2018-03-01 00:00:00

abstract：:Meiotic recombination depends upon the tightly coordinated regulation of chromosome dynamics and is essential for the production of haploid gametes. Central to this process is the formation and repair of meiotic double-stranded breaks (DSBs), which must take place within the constraints of a specialized chromatin arch...

journal_title：Genetics

authors： Turcotte CA,Sloat SA,Rigothi JA,Rosenkranse E,Northrup AL,Andrews NP,Checchi PM

更新日期：2018-03-01 00:00:00

abstract：:Chromatin is organized and compacted in the nucleus through the association of histones and other proteins, which together control genomic activity. Two broad types of chromatin can be distinguished: euchromatin, which is generally transcriptionally active, and heterochromatin, which is repressed. Here we examine the ...

journal_title：Genetics

authors： Ahringer J,Gasser SM

更新日期：2018-02-01 00:00:00

abstract：:How the brain makes trillions of synaptic connections using a genome of only 20,000 genes is a major question in modern neuroscience. Alternative splicing is one mechanism that can increase the number of proteins produced by each gene, but its role in regulating synapse formation is poorly understood. In Drosophila, p...

journal_title：Genetics

authors： Kerwin SK,Li JSS,Noakes PG,Shin GJ,Millard SS

更新日期：2018-02-01 00:00:00

abstract：:Mitotic fidelity is ensured by achieving biorientation on all paired chromosomes. The key signal for proper chromosome alignment is the tension between sister chromatids created by opposing poleward force from the spindles. In the budding yeast, the tension-sensing function requires that the Shugoshin protein, Shugosh...

journal_title：Genetics

authors： Buehl CJ,Deng X,Luo J,Buranasudja V,Hazbun T,Kuo MH

更新日期：2018-02-01 00:00:00

abstract：:N6-methyladenosine (m6A), catalyzed by Mettl3 methyltransferase, is a highly conserved epigenetic modification in eukaryotic messenger RNA (mRNA). Previous studies have implicated m6A modification in multiple biological processes, but the in vivo function of m6A has been difficult to study, because mettl3 mutants are ...

journal_title：Genetics

authors： Xia H,Zhong C,Wu X,Chen J,Tao B,Xia X,Shi M,Zhu Z,Trudeau VL,Hu W

更新日期：2018-02-01 00:00:00

abstract：:Meiosis is a specialized cell division that generates gametes, such as eggs and sperm. Errors in meiosis result in miscarriages and are the leading cause of birth defects; however, the molecular origins of these defects remain unknown. Studies in model organisms are beginning to identify the genes and pathways importa...

journal_title：Genetics

authors： Blyth J,Makrantoni V,Barton RE,Spanos C,Rappsilber J,Marston AL

更新日期：2018-02-01 00:00:00

abstract：:Aggression is a complex social behavior that is widespread in nature. To date, only a limited number of genes that affect aggression have been identified, in large part because the complexity of the phenotype makes screening difficult and time-consuming regardless of the species that is studied. We discovered that agg...

journal_title：Genetics

authors： Davis SM,Thomas AL,Liu L,Campbell IM,Dierick HA

更新日期：2018-01-01 00:00:00

abstract：:Genetic material sequenced from ancient samples is revolutionizing our understanding of the recent evolutionary past. However, ancient DNA is often degraded, resulting in low coverage, error-prone sequencing. Several solutions exist to this problem, ranging from simple approach, such as selecting a read at random for ...

journal_title：Genetics

authors： Schraiber JG

更新日期：2018-01-01 00:00:00

abstract：:Transposons can impact the host genome by altering gene expression and participating in chromosome rearrangements. Therefore, organisms evolved different ways to minimize the level of transposition. In Saccharomyces cerevisiae and its close relative S. paradoxus, Ty1 copy number control (CNC) is mediated by the self-e...

journal_title：Genetics

authors： Ahn HW,Tucker JM,Arribere JA,Garfinkel DJ

更新日期：2017-12-01 00:00:00

abstract：:Motile and immotile (or primary) cilia are microtubule-based structures that mediate multiple cellular functions, including the transduction of environmental cues, developmental signaling, cellular motility, and modulation of fluid flow. Although their core architectures are similar, motile and primary cilia exhibit m...

journal_title：Genetics

authors： Kazatskaya A,Kuhns S,Lambacher NJ,Kennedy JE,Brear AG,McManus GJ,Sengupta P,Blacque OE

更新日期：2017-12-01 00:00:00

abstract：:In a genetic screen for mutants showing modified splicing of an alternatively spliced GFP reporter gene in Arabidopsis thaliana, we identified mutations in genes encoding the putative U1 small nuclear ribonucleoprotein (snRNP) factors RBM25 and PRP39a. The latter has not yet been studied for its role in pre-messenger ...

journal_title：Genetics

authors： Kanno T,Lin WD,Fu JL,Chang CL,Matzke AJM,Matzke M

更新日期：2017-12-01 00:00:00

abstract：:The distribution of fitness effects (DFE) encompasses the fraction of deleterious, neutral, and beneficial mutations. It conditions the evolutionary trajectory of populations, as well as the rate of adaptive molecular evolution (α). Inferring DFE and α from patterns of polymorphism, as given through the site frequency...

journal_title：Genetics

authors： Tataru P,Mollion M,Glémin S,Bataillon T

更新日期：2017-11-01 00:00:00

abstract：:Diversity of the founding population of Human Immunodeficiency Virus Type 1 (HIV-1) transmissions raises many important biological, clinical, and epidemiological issues. In up to 40% of sexual infections, there is clear evidence for multiple founding variants, which can influence the efficacy of putative prevention me...

journal_title：Genetics

authors： Romero-Severson EO,Bulla I,Hengartner N,Bártolo I,Abecasis A,Azevedo-Pereira JM,Taveira N,Leitner T

更新日期：2017-11-01 00:00:00

abstract：:The endoplasmic reticulum (ER) is an extensive organelle in neurons with important roles at synapses including the regulation of cytosolic Ca2+, neurotransmission, lipid metabolism, and membrane trafficking. Despite intriguing evidence for these crucial functions, how the presynaptic ER influences synaptic physiology ...

journal_title：Genetics

authors： Kikuma K,Li X,Kim D,Sutter D,Dickman DK

更新日期：2017-11-01 00:00:00

abstract：:Eukaryotic chromosome segregation requires a protein complex known as the kinetochore that mediates attachment between mitotic spindle microtubules and centromere-specific nucleosomes composed of the widely conserved histone variant CENP-A. Mutations in kinetochore proteins of the fission yeast Schizosaccharomyces pom...

journal_title：Genetics

authors： Gao C,Langbein L,Kamal F,George AA,Walworth NC

更新日期：2017-10-01 00:00:00

abstract：:Selection during evolution, whether natural or artificial, acts through the phenotype. For multifaceted phenotypes such as plant and inflorescence architecture, the underlying genetic architecture is comprised of a complex network of interacting genes rather than single genes that act independently to determine the tr...

journal_title：Genetics

authors： Studer AJ,Wang H,Doebley JF

更新日期：2017-10-01 00:00:00

abstract：:Circadian clocks organize the metabolism, physiology, and behavior of organisms throughout the day-night cycle by controlling daily rhythms in gene expression at the transcriptional and post-transcriptional levels. While many transcription factors underlying circadian oscillations are known, the splicing factors that ...

journal_title：Genetics

authors： Beckwith EJ,Hernando CE,Polcowñuk S,Bertolin AP,Mancini E,Ceriani MF,Yanovsky MJ

更新日期：2017-10-01 00:00:00

abstract：:Eukaryotic genomes are rich in transcription units encoding "long noncoding RNAs" (lncRNAs). The purpose of all this transcription is unclear since most lncRNAs are quickly targeted for destruction during synthesis or shortly thereafter. As debates continue over the functional significance of many specific lncRNAs, su...

journal_title：Genetics

authors： Ard R,Allshire RC,Marquardt S

更新日期：2017-10-01 00:00:00

abstract：:Y chromosome function, structure and evolution is poorly understood in many species, including the Anopheles genus of mosquitoes-an emerging model system for studying speciation that also represents the major vectors of malaria. While the Anopheline Y had previously been implicated in male mating behavior, recent data...

journal_title：Genetics

authors： Bernardini F,Galizi R,Wunderlich M,Taxiarchi C,Kranjc N,Kyrou K,Hammond A,Nolan T,Lawniczak MNK,Papathanos PA,Crisanti A,Windbichler N

更新日期：2017-10-01 00:00:00

abstract：:While bacteria divide clonally, horizontal gene transfer followed by homologous recombination is now recognized as an important contributor to their evolution. However, the details of how the competition between clonality and recombination shapes genome diversity remains poorly understood. Using a computational model,...

journal_title：Genetics

authors： Dixit PD,Pang TY,Maslov S

更新日期：2017-09-01 00:00:00

abstract：:Renal agenesis (RA) is one of the more extreme examples of congenital anomalies of the kidney and urinary tract (CAKUT). Bilateral renal agenesis is almost invariably fatal at birth, and unilateral renal agenesis can lead to future health issues including end-stage renal disease. Genetic investigations have identified...

journal_title：Genetics

authors： Brophy PD,Rasmussen M,Parida M,Bonde G,Darbro BW,Hong X,Clarke JC,Peterson KA,Denegre J,Schneider M,Sussman CR,Sunde L,Lildballe DL,Hertz JM,Cornell RA,Murray SA,Manak JR

更新日期：2017-09-01 00:00:00

abstract：:Interactions between Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR) RNAs and CRISPR-associated (Cas) proteins form an RNA-guided adaptive immune system in prokaryotes. The adaptive immune system utilizes segments of the genetic material of invasive foreign elements in the CRISPR locus. The loci are ...

journal_title：Genetics

authors： Fu BX,Wainberg M,Kundaje A,Fire AZ

更新日期：2017-08-01 00:00:00

abstract：:Heparan sulfates (HS) are linear polysaccharides with complex modification patterns, which are covalently bound via conserved attachment sites to core proteins to form heparan sulfate proteoglycans (HSPGs). HSPGs regulate many aspects of the development and function of the nervous system, including cell migration, mor...

journal_title：Genetics

authors： Saied-Santiago K,Townley RA,Attonito JD,da Cunha DS,Díaz-Balzac CA,Tecle E,Bülow HE

更新日期：2017-08-01 00:00:00

abstract：:The micronutrient boron is essential in maintaining the structure of plant cell walls and is critical for high yields in crop species. Boron can move into plants by diffusion or by active and facilitated transport mechanisms. We recently showed that mutations in the maize boron efflux transporter ROTTEN EAR (RTE) caus...

journal_title：Genetics

authors： Chatterjee M,Liu Q,Menello C,Galli M,Gallavotti A

更新日期：2017-08-01 00:00:00

abstract：:The genetic basis of stochastic variation within a defined environment, and the consequences of such micro-environmental variance for fitness are poorly understood . Using a multigenerational breeding design in Drosophila serrata, we demonstrated that the micro-environmental variance in a set of morphological wing tra...

journal_title：Genetics

authors： Sztepanacz JL,McGuigan K,Blows MW

更新日期：2017-08-01 00:00:00

abstract：:The degree to which genomic architecture varies across space and time is central to the evolution of genomes in response to natural selection. Bulked-segregant mapping combined with pooled sequencing provides an efficient means to estimate the effect of genetic variants on quantitative traits. We develop a novel likel...

journal_title：Genetics

authors： Monnahan PJ,Kelly JK

更新日期：2017-07-01 00:00:00

abstract：:Genomic prediction methods based on multiple markers have potential to include nonadditive effects in prediction and analysis of complex traits. However, most developments assume a Hardy-Weinberg equilibrium (HWE). Statistical approaches for genomic selection that account for dominance and epistasis in a general conte...

journal_title：Genetics

authors： Vitezica ZG,Legarra A,Toro MA,Varona L

更新日期：2017-07-01 00:00:00

abstract：:Understanding variation in allele frequencies across populations is a central goal of population genetics. Classical models for the distribution of allele frequencies, using forward simulation, coalescent theory, or the diffusion approximation, have been applied extensively for demographic inference, medical study des...

journal_title：Genetics

authors： Jouganous J,Long W,Ragsdale AP,Gravel S

更新日期：2017-07-01 00:00:00

abstract：:Gene silencing mediated by dsRNA (RNAi) can persist for multiple generations in Caenorhabditis elegans (termed RNAi inheritance). Here we describe the results of a forward genetic screen in C. elegans that has identified six factors required for RNAi inheritance: GLH-1/VASA, PUP-1/CDE-1, MORC-1, SET-32, and two novel ...

journal_title：Genetics

authors： Spracklin G,Fields B,Wan G,Becker D,Wallig A,Shukla A,Kennedy S

更新日期：2017-07-01 00:00:00

abstract：:Mitomycin C (MMC) is a genotoxic agent that induces DNA cross-links, DNA alkylation, and the production of reactive oxygen species (ROS). MMC induces the SOS response and RpoS regulons in Escherichia coli SOS-encoded functions are required for DNA repair, whereas the RpoS regulon is typically induced by metabolic stre...

journal_title：Genetics

authors： Dapa T,Fleurier S,Bredeche MF,Matic I

更新日期：2017-07-01 00:00:00

abstract：:Resident gut bacteria are constantly influencing the immune system, yet the role of the immune system in shaping microbiota composition during an organism's life span has remained unclear. Experiments in mice have been inconclusive due to differences in husbandry schemes that led to conflicting results. We used Drosop...

journal_title：Genetics

authors： Mistry R,Kounatidis I,Ligoxygakis P

更新日期：2017-06-01 00:00:00